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Diana Mitchell

Diana Mitchell

Assistant Professor

Office

Life Sciences South 150

Phone

208-885-0305

Mailing Address

Dept. of Biological Sciences
University of Idaho
875 Perimeter MS 3051
Moscow, Idaho 83844-3051

Research: Cellular & Molecular Biology

My current research interests involve immune cell function in the central nervous system, specifically the retina. I am particularly interested in microglia, which are resident innate immune cells of the central nervous system. Current efforts employ the zebrafish model system and seek to understand the role of microglia in the development of the retina, how microglia respond to neuronal cell death, and how they may support or be detrimental to neuronal regeneration.

I also contribute to research efforts in Dr. Deborah Stenkamp’s lab, where we are investigating mechanisms of photoreceptor fate decisions in the developing retina.

My current research interests involve immune cell function in the central nervous system, specifically the retina. I am particularly interested in microglia, which are resident innate immune cells of the central nervous system. Current efforts employ the zebrafish model system and seek to understand the role of microglia in the development of the retina, how microglia respond to neuronal cell death, and how they may support or be detrimental to neuronal regeneration.

I also contribute to research efforts in Dr. Deborah Stenkamp’s lab, where we are investigating mechanisms of photoreceptor fate decisions in the developing retina.

  • Mackin RD, Frey RA, Gutierrez C, Farre AA, Kawamura S, Mitchell DM, Stenkamp DL. Endocrine Regulation of Multichromatic Color Vision. PNAS. In press.
  • Mitchell DM*, Sun C, Hunter SS, New DD, Stenkamp DL. 2019. Regeneration associated transcriptional signature of microglia and macrophages. Scientific Reports. *Lead and corresponding author
  • McGinn TE, Galicia CA, Leoni DC, Partington NN, Mitchell DM, Stenkamp DL. Rewiring the regenerated zebrafish retina: Reemergence of bipolar neurons and cone-bipolar circuitry following an inner retinal lesion. 2019. Frontiers in Cell and Developmental Biology.
  • Chi Sun, Mitchell DM, Stenkamp DL. 2018. Isolation of photoreceptors from mature, developing, and regenerated zebrafish retinas, and of microglia/macrophages from regenerating zebrafish retinas. Experimental Eye Research. 177:130-144.
  • Mitchell DM*, Lovel AG, Stenkamp DL. 2018. Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina. Journal of Neuroinflammation. 15:163. *Lead and corresponding author
  • McGinn TE, Mitchell DM, Meighan PC, Partington N, Leoni DC, Jenkins CE, Stenkamp DL. Restoration of Dendritic Complexity, Functional Connectivity, and Diversity of Regenerated Retinal Bipolar Neurons in Adult Zebrafish. J. Neurosci. 38:120–36.
  • Mitchell DM*, Stevens CB*, Hunter SS, Frey RA, Kawamura S, and Stenkamp DL. 2015. Retinoic acid signaling regulates differential expression of the tandemly-duplicated long wavelength- sensitive cone opsins in zebrafish. Plos Genetics. 11(8):e1005483 *Equal contribution to this work.
  • Chen B*, Legant WR*, Wang K, Shao L, Milkie DE, Davidson MW, Janetopoulos C, Wu XS, Hammer III JA, Liu Z, English BP, Mimori-Kiyosue Y, Romero DP, Ritter AT, Lippincott- Schwartz J, Fritz-Laylin L, Mullins RD, Mitchell DM, Bembenek JN, Reymann A-C, Bohme R, Grill SW, Wang JT, Seydoux G, Tulu US, Kiehart DP, Betzig E. 2014. Lattice Light-Sheet Microscopy: Imaging Molecules to Embryos at High Spatiotemporal Resolution. Science. 346, 1257998.
  • Mitchell DM, Uehlein-Klebanow LR,, and Bembenek JN. 2014. Protease-Dead Separase is Dominant Negative in the C. Elegans Embryo. PloS One, 9(9): e108188.
  • Mitchell DM and Williams MA. 2013. Disparate roles for STAT5 in primary and secondary CTL responses. Journal of Immunology, 190: 3390-3398.
  • Jay DC, Mitchell DM, and Williams MA. 2013. Bim mediates the elimination of functionally unfit Th1 responders from the memory pool. PLoS One, 8(6): e67363.
  • Mitchell DM, Ravkov ER, and Williams MA. 2010. Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ Effector and Memory T cells. Journal of Immunology, 184: 6719-6730.

Contact

Department of Biological Sciences

Physical Address:
Life Sciences South 252

Mailing Address:
875 Perimeter Drive MS 3051
Moscow, ID 83844-3051

Phone: 208-885-6280

Fax: 208-885-7905

Email: biosci@uidaho.edu

Web: Department of Biological Sciences