Ching-An Peng, Ph.D.
Ching-An Peng, Ph.D.
Professor and Chair
Engineering Physics 421
University of Idaho
875 Perimeter Drive, MS 0904
Moscow, Idaho 83844-0904
- Ph.D., University of Michigan, 1995
- M.S., University of Notre Dame, 1990
- B.S., National Taiwan University, 1985
- Drug/gene delivery
- Nano/bio technology
- Cellular/tissue engineering
Ching-An Peng started his academic career as an assistant professor at the University of Southern California in Chemical Engineering Department and later on promoted to associate professor with tenure. He then worked at the National Taiwan University as a full professor and at Michigan Technological University as the first holder of the James and Lorna Mack Endowed Chair in Bioengineering. In 2015, he joined the University of Idaho. Over the course of his academic career, Peng has been involved with research in drug/gene delivery using viral and nonviral vectors as well as ultrasonic device, developing phagocytosis-resistant perfluorocarbon-based oxygen carriers using PEGylated fluorosurfactant and CD47 ligand, photothermolysis of cancer cells using nanomaterials, and detection of antiviral agents using nanobiosensors. A few of Peng’s studies are summarized below.
Polymeric drug/gene nanocarriers for gene-directed enzyme prodrug therapy are designed and synthesized to specifically target cancer cells and control the release of cytotoxic drugs inside the cancer cells for augmenting the effectiveness of anticancer treatment. Several enzyme/prodrug pairs and anticancer drugs have been coupled with polymeric micellar nanoparticles to deliver into cancer cells and showed anticancer activity. To achieve the goal of long blood circulation of drug/gene carriers, CD47-streptavidin fusion protein expressed in bacteria and purified by affinity chromatography is conjugated on biotinylated nanocarriers to explore its anti-phagocytic capability. Results show CD47-tagged nanoparticles can prevent phagocytosis by macrophage to a large extend. For the enhancement of gene delivery efficiency, both viral or nonviral approaches have been investigated.
Developing fast and efficient screening technology has its merits of identifying potential drugs against viral diseases that still lack of effective prevention or treatment. Quantum dot, an emerging probe for biological imaging and medical diagnostics, is employed to form complexes with virus and used as fluorescent imaging probes for exploring potential antiviral therapeutics. Ultrasound contrast perfluorocarbon microbubble stabilized with PEG-based fluorosurfactant has been incorporated with nanomaterials to enhance the detecting capability. Perfluorocarbon microbubble can be further used to carry therapeutic drugs or genes to make it as a theranostic agent. Carbon nanotube and gold nanorod functionalized with tumor-specific monoclonal antibodies have been utilized along with near-infrared laser to selectively induce photothermolysis of specific malignant cells from a mixed cell population.
- Chen, Y-H, Wang, C-H, Chang, C-W, Peng, C-A, In situ formation of viruses tagged with quantum dots, Integrative Biology 2: 258-264, 2010.
- Peng, C-A, Wang, C-H, Wang, W-L. Rapid antiviral assay using QD-tagged fish virus as imaging nanoprobe, J Virological Methods169: 412-415, 2010.
- Wang, C-H, Chiou, S-H, Chou, C-P, Chen, Y-C, Huang, Y-J, Peng, C-A. Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody, Nanomedicine: Nanotechnology, Biology, and Medicine 7: 69-79, 2011.
- Peng, C-A, Wang, C-H. Anti-neuroblastoma activity of gold nanorods bound with GD2 monoclonal antibody under near-infrared laser irradiation, Cancers 3: 227-240, 2011.
- Anbarasan, R, Peng, C-A. Synthesis of rose bengal/folic acid functionalized multiwall carbon nanotubes, J Mater Sci 46: 992-998, 2011.
- Wang, C-H, Chang, C-W, Peng, C-A. Gold nanorods stabilized by thiolated chitosan as photothermal absorbers for cancer cell treatment, J Nanoparticle Res 13: 2749-2758, 2011.
- Peng, C-A, Wang, C-H. Anti-enteroviral activity of microalgal extracts probed by bionanohybrids of quantum dots and viruses, BioNanoSci 1: 144-152, 2011.
- Anbarasan, R, Peng, C-A. Effect of multiwall carbon nanotube and Au nanoparticle on the structure-property relationship of poly(N-isopropyl acryamide), J Appl Polym Sci 124: 3996-4006, 2012.
- Salehi, N, Peng, C-A. Gene transfection of Toxoplasma gondii using PEI/DNA polyplexes, J Microbiological Methods 91:133-137, 2012.
- Sawdon AJ, Peng CA. Guanosine-based antiviral acyclovir incorporated in ring-opening polymerization of ε-caprolactone, Macromol Res 21:1-4, 2013.
- Sawdon AJ, Peng CA. Engineering antiphagocytic biomimetic drug carriers, Ther Deliv 4:825-839, 2013.
- Sawdon AJ, Weydemeyer E, Peng CA. Tumor photothermolysis: using carbon nanomaterials for cancer therapy, European J Nanomedicine 5:131-140, 2013.
- Peng CA, Pachpinde SM. Longitudinal plasmonic detection of glucose using gold nanorods, Nanomaterials Nanotechnology 4:9, 2014.
- Sawdon AJ, Weydemeyer E, Peng CA. Antitumor therapy using nanomaterial-mediated thermolysis, J Biomedical Nanotechnology 10:1894-1917, 2014.
- Peng CA, Wang CH. Cancer stem-like cells photothermolysed by gold nanorod-mediated near-infrared irradiation. International J Nanotechnology 11:1157-1165, 2014.
- Sawdon AJ, Peng CA. Polymeric micelles for acyclovir drug delivery. Colloids & Surfaces B: Biointerfaces 122:738-745, 2014
- Sawdon AJ, Peng CA. Ring-opening polymerization of ε-caprolactone initiated by ganciclovir (GCV) for the preparation of GCV-tagged polymeric micelles. Molecules 20:2857-2867, 2015
- Weydemeyer E, Sawdon AJ, Peng CA. Controlled cutting and hydroxyl functionalization of carbon nanotubes through autoclaving and sonication in hydrogen peroxide. Chemical Communications 51:5939-5942, 2015
- Sawdon AJ, Peng CA. Internal deoxygenation of tubular photobioreactor for mass production of microalgae by perfluorocarbon emulsions, J Chemical Technology Biotechnology 90:1426-1432, 2015