Shirley Luckhart

• Regulation of malaria parasite development in the mosquito host — fundamental cell signaling pathways, innate defenses, biology of the blood feeding interface and metabolic regulation of sporogony.
• Innate immunity to malaria parasite development in the mammalian host — mechanisms of altered intestinal barrier during parasite infection, regulation of innate responses in the liver and spleen to parasite infection, effects of transmission blocking compounds on disease and transmission.
• Effects of malaria-induced changes to allergic factors in blood on mosquito physiology – response to host cues, flight and feeding behavior, infection with malaria parasites.
• Efforts to integrate teaching, research and outreach across plant, animal and human diseases — University of Idaho Institute for Health in the Human Ecosystem.

• Céspedes N, Donnelly EL, Hansten G, Fellows AM, Dobson M, Kaylor HL, Coles TA, Schauer J, Van de Water J, Luckhart S. Mast cell-derived IL-10 protects intestinal barrier integrity during malaria in mice and regulates parasite transmission to Anopheles stephensi with a female-biased immune response. Infect Immun. 2024 Mar 12;92(3):e0036023. doi: 10.1128/iai.00360-23.
• Riske BF, Luckhart S, Riehle MA. Starving the Beast: Limiting Coenzyme A Biosynthesis to Prevent Disease and Transmission in Malaria. Int J Mol Sci. 2023 Sep 10;24(18):13915. doi: 10.3390/ijms241813915.
• Coles TA, Briggs AM, Hambly MG, Céspedes N, Fellows AM, Kaylor HL, Adams AD, Van Susteren G, Bentil RE, Robert MA, Riffell JA, Lewis EE, Luckhart S. Ingested histamine and serotonin interact to alter Anopheles stephensi feeding and flight behavior and infection with Plasmodium parasites. Front Physiol. 2023 July 23; 14: DOI=10.3389/fphys.2023.1247316.
• Stefanovska T, Luckhart S, Ripa L, Stevens G, Lewis E. Steinernema carpocapsae. Trends Parasitol. 2023 May;39(5):400-401. doi: 10.1016/j.pt.2023.01.002.
• Oyieko J, Copeland NK, Otieno S, Kifude C, Ocholla S, Hutter J, Smith H, Roberds A, Luckhart S, Stewart VA. Longitudinal and Cross-sectional Analyses of Asymptomatic HIV-1/Malaria Co-infection in Kisumu County, Kenya. Am J Trop Med Hyg. 2022 Nov 21;108(1):85-92. doi: 10.4269/ajtmh.22-0035.
• Kifude CM, Roberds A, Oyieko J, Ocholla S, Otieno S, Waitumbi JN, Hutter J, Smith H, Copeland NK, Luckhart S, Stewart VA. Initiation of anti-retroviral/Trimethoprim-Sulfamethoxazole therapy in a longitudinal cohort of HIV-1 positive individuals in Western Kenya rapidly decreases asymptomatic malarial parasitemia. Front Cell Infect Microbiol. 2022 Nov 24;12:1025944. doi: 10.3389/fcimb.2022.1025944.
• Thakre N, Simão Gurge RM, Isoe J, Kivi H, Strickland J, Delacruz LR, Rodriguez AM, Haney R, Sadeghi R, Joy T, Chen M, Luckhart S, Riehle MA. Manipulation of pantothenate kinase in Anopheles stephensi suppresses pantothenate levels with minimal impacts on mosquito fitness. Insect Biochem Mol Biol. 2022 Oct;149:103834. doi: 10.1016/j.ibmb.2022.103834.
• Roberds A, Kifude C, Oyieko J, Ocholla S, Mutunga J, Oullo D, Waga C, Li Z, Luckhart S, Stewart VA. Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles mosquitoes. Front Cell Infect Microbiol. 2022 Sep 16;12:934641. doi: 10.3389/fcimb.2022.934641.
• Donnelly EL, Céspedes N, Hansten G, Wagers D, Briggs AM, Lowder C, Schauer J, Haapanen L, Van de Water J, Luckhart S. The basophil IL-18 receptor precisely regulates the host immune response and malaria-induced intestinal permeability and alters parasite transmission to mosquitoes without effect on gametocytemia. Immunohorizons. 2022 Aug 19;6(8):630-641. doi: 10.4049/immunohorizons.2200057.
• Donnelly EL, Céspedes N, Hansten G, Wagers D, Briggs AM, Lowder C, Schauer J, Garrison SM, Haapanen L, Van de Water J, Luckhart S. Basophil depletion alters host immunity, intestinal permeability, and mammalian host-to-mosquito transmission in malaria. Immunohorizons. 2022 Aug 15;6(8):581-599. doi: 10.4049/immunohorizons.2200055.
• Briggs AM, Hambly MG, Simão-Gurge RM, Garrison SM, Khaku Z, Van Susteren G, Lewis EE, Riffell JA, Luckhart S. Anopheles stephensi Feeding, Flight Behavior, and Infection With Malaria Parasites are Altered by Ingestion of Serotonin. Front Physiol. 2022 Jun 7;13:911097. doi: 10.3389/fphys.2022.911097.
  
• Trammell CE, Ramirez G, Sanchez-Vargas I, St Clair LA, Ratnayake OC, Luckhart S, Perera R, Goodman AG. Coupled small molecules target RNA interference and JAK/STAT signaling to reduce Zika virus infection in Aedes aegypti. PLoS Pathog. 2022 Apr 4;18(4):e1010411. doi: 10.1371/journal.ppat.1010411.
  
• Céspedes N, Donnelly EL, Lowder C, Hansten G, Wagers D, Briggs AM, Schauer J, Haapanen L, Åbrink M, Van de Water J, Luckhart S. Mast Cell Chymase/Mcpt4 Suppresses the Host Immune Response to Plasmodium yoelii, Limits Malaria-Associated Disruption of Intestinal Barrier Integrity and Reduces Parasite Transmission to Anopheles stephensi. Front Immunol. 2022 Jan 27;13:801120. doi: 10.3389/fimmu.2022.801120.
  
• Donnelly E, de Water JV, Luckhart S. Malaria-induced bacteremia as a consequence of multiple parasite survival strategies. Curr Res Microb Sci. 2021 May 8;2:100036. doi: 10.1016/j.crmicr.2021.100036.
  
• Hun LV, Cheung KW, Brooks E, Zudekoff R, Luckhart S, Riehle MA. Increased insulin signaling in the Anopheles stephensi fat body regulates metabolism and enhances the host response to both bacterial challenge and Plasmodium falciparum infection. Insect Biochem Mol Biol. 2021 Dec;139:103669. doi: 10.1016/j.ibmb.2021.103669.
• Kifude C, Stiffler D, Rockabrand D, Miller R, Parsons E, Ocholla S, Dizon NI, Torrevillas BK, Waitumbi J, Oyieko J, Luckhart S, Stewart VA. Asymptomatic falciparum and Non-falciparum Malarial Parasitemia in Adult Volunteers with and without HIV-1 Coinfection in a Cohort Study in Western Kenya. Am J Trop Med Hyg. 2021 Jun 7;105(1):159–66. doi: 10.4269/ajtmh.21-0012.
  
• Simão-Gurge RM, Thakre N, Strickland J, Isoe J, Delacruz LR, Torrevillas BK, Rodriguez AM, Riehle MA, Luckhart S. Activation of Anopheles stephensi Pantothenate Kinase and Coenzyme A Biosynthesis Reduces Infection with Diverse Plasmodium Species in the Mosquito Host. Biomolecules. 2021 May 29;11(6):807. doi: 10.3390/biom11060807.
  
• Rodriguez AM, Hambly MG, Jandu S, Simão-Gurge R, Lowder C, Lewis EE, Riffell JA, Luckhart S. Histamine Ingestion by Anopheles stephensi Alters Important Vector Transmission Behaviors and Infection Success with Diverse Plasmodium Species. Biomolecules. 2021 May 11;11(5):719. doi: 10.3390/biom11050719.
  
• Andrews KR, Hunter SS, Torrevillas BK, Céspedes N, Garrison SM, Strickland J, Wagers D, Hansten G, New DD, Fagnan MW, Luckhart S. A new mouse SNP genotyping assay for speed congenics: combining flexibility, affordability, and power. BMC Genomics. 2021 May 24;22(1):378. doi: 10.1186/s12864-021-07698-9.
  
• Roberds A, Ferraro E, Luckhart S, Stewart VA. HIV-1 Impact on Malaria Transmission: A Complex and Relevant Global Health Concern. Front Cell Infect Microbiol. 2021 Apr 12;11:656938. doi: 10.3389/fcimb.2021.656938.
  
• Tao H, Li L, Liao NS, Schluns KS, Luckhart S, Sleasman JW, Zhong XP. Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development. Front Immunol. 2021 Mar 1;12:623280. doi: 10.3389/fimmu.2021.623280.
  
• Stiffler DM, Oyieko J, Kifude CM, Rockabrand DM, Luckhart S, Stewart VA. HIV-1 Infection Is Associated With Increased Prevalence and Abundance of Plasmodium falciparum Gametocyte-Specific Transcripts in Asymptomatic Adults in Western Kenya. Front Cell Infect Microbiol. 2021 Feb 5;10:600106. doi: 10.3389/fcimb.2020.600106.
  
• Oringanje C, Delacruz LR, Han Y, Luckhart S, Riehle MA. Overexpression of Activated AMPK in the Anopheles stephensi Midgut Impacts Mosquito Metabolism, Reproduction and Plasmodium Resistance. Genes (Basel). 2021 Jan 19;12(1):119. doi: 10.3390/genes12010119.
  

• University of Idaho, Alumni Award for Inspirational Mentor, 2021
• Founders’ Memorial Award, Entomological Society of America, 2018
• University of Idaho, Alumni Award for Excellence in Mentoring, 2019
• Career Excellence Award in Medical, Urban, and Veterinary Entomology, Pacific Branch of the Entomological Society of America, 2017.
• UC Davis Award for Excellence in Service to Graduate Students, UC Davis Graduate Student Association, 2016.
• Fellow, American Society for Tropical Medicine and Hygiene, 2014.
• Outstanding Mentor Award, The Consortium for Women and Research, UC Davis, 2012.
• Top health invention for 2010, Time Magazine, for collaborative work with University of Arizona on the "malaria-proof mosquito" (Corby-Harris and Drexler et al. 2010, PLoS Pathogens 6(7):e1001003).
• Justin Morrill Award for Contributions to Graduate Education in Entomology, Virginia Tech, 2004.
• National Research Council Postdoctoral Fellow, United States Army, Walter Reed Army Institute of Research, 1995-1998.
• John Henry Comstock Award for Outstanding Ph.D. in Entomology, Eastern Branch of the Entomological Society of America, 1995.

Shirley Luckhart, professor of entomology, plant pathology and nematology in the College of Agricultural and Life Sciences and professor of biological sciences in the College of Science is an expert in arthropod-borne infectious diseases. Her background training includes natural resource conservation, entomology, biochemistry, microbiology, parasitology and innate immunity. Luckhart’s work for the past 25 plus years has focused on malaria, a disease that adversely affects poor and underdeveloped countries throughout the tropics. In particular, her lab has studied murine and non-human primate malaria parasite development and transmission, transmission of the human parasite Plasmodium falciparum using cultured parasites and P. falciparum transmission under field conditions in endemic countries. She is particularly interested in innate immunity of host-parasite interactions in the mosquito and mammalian host and developing interventions to block both disease and transmission.