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Department of Chemistry

Physical Address:
Renfrew Hall 116

Mailing Address:
875 Perimeter Dr, MS 2343
Moscow, ID 83844-2343

Phone: 208-885-6552

Fax: 208-885-6173


Web: Department of Chemistry

Selected Recent Publications

2016 Selected Publications

Next generation bis-locked nucleic acids with stacking linker and 2´-glycylamino-LNA show enhanced invasion into supercoiled duplex DNA.
Geny, S.; Moreno, P. M. D; Krzywkowski, T.; Andersen, N. K.; Isse, A. J.; El-Madani, A. M.; Lou, C.; Pabon, Y. V.; Gissberg, O.; Anderson, B. A.; Zaghloul, E. M.; Zain, R.; Hrdlicka, P. J.; Jørgensen, P. T.; Nilsson, M.; Lundin, K. E.; Pedersen, E. B.; Wengel, J.; Smith, C. I. E.  Nucleic Acids Research, in press.

Increased duplex stabilization in porphyrin-LNA zipper arrays with structure dependent excitonic coupling.
Singleton, D. G.; Hussain, R.; Siligardi, G.; Kumar, P.; Hrdlicka, P. J.; Berova, N.; Stulz, E. Org. Biomol. Chem., 2016, 14, 149-157.

2015 Selected Publications

A Study of the Electrochemical Properties of a New Graphitic Material: GUITAR” Isaiah O. Gyan, Peter Wojcik, D. Eric Aston, David N. McIlroy and I. Francis Cheng, ChemElectroChem, 2015, 2, 700-706.

"Electrochemical Study of Biologically Relevant Molecules at Electrodes Constructed from GUITAR, a New Carbon Allotrope." Isaiah O. Gyan and I. Francis Cheng, accepted Microchemical Journal, 2015, 122, 39-44.

Open source and DIY hardware for DNA nanotechnology labs. Journal of Biological Methods (2015). Tulsi R. Damase, Daniel Stephens, Adam Spencer, P. B. Allen

3D Printing with Nucleic Acid Adhesives. ACS Biomatererials Science and Engineering (2015) P.B. Allen, Z. Khaing, C.E. Schmidt, A.D. Ellington.

Bulged Invader probes: Activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles.
Guenther, D. C.; Karmakar, S.; Hrdlicka, P. J. Chem. Commun., 2015, 51, 15051-15054.

Locked Nucleic Acid (LNA) induced effect on hybridization and fluorescence properties of oligodeoxyribonucleotides modified with nucleobase-functionalized DNA monomers.
Kaura, M.; Hrdlicka, P. J. Org. Biomol. Chem., 2015, 13, 7236-7247.

Recognition of double-stranded DNA using energetically activated duplexes modified with N2′-pyrene-, perylene-, or coronene-functionalized 2′-N-methyl-2′-amino-DNA monomers.
Anderson, B. A.; Onley, J. J.; Hrdlicka, P. J. J. Org. Chem., 2015, 80, 5395-5406 (Featured Article).

Synthesis and characterization of oligodeoxyribonucleotides modified with 2′-thio-2′-deoxy-2′-S-(pyren-1-yl)methyluridine. 
Anderson, B. A.; Hrdlicka, P. J. Bioorg. Med. Chem. Lett., 2015, 25, 3999-4004

Invader probes: Harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications. 
Guenther, D. C.; Anderson, G. H.; Karmakar, S.; Anderson, B. A.; Didion, B. A.; Guo, W.; Verstegen, J. P.; and Hrdlicka, P. J. Chem. Sci., 2015, 6, 5006-5015.

Versatile Polyiodopyrazoles: Synthesis and Biocidal Promise
Chand, D.; Shreeve, J. M. Chemical Communications 2015, 15, 3438-3441.

Energetic Salts with π-Stacking and Hydrogen-Bonding Interactions Lead the Way to Future Energetic Materials
Zhang, J.; Zhang, Q.; Vo, T. T.; Parrish, D. A.; Shreeve, J. M. Journal of the American Chemical Society, 2015, 137, 1697-1704.

The Many Faces of FOX-7: Precursor to High Performance Energetic Materials
Gao, H.; Shreeve, J. M. Angewandte Chemie Int. Ed. 2015, 54, 6335-6338.

Energetic Multi-functionalized Nitraminopyrazoles and Their Ionic Derivatives: Ternary Hydrogen-bond Induced High Energy Density Materials
Yin, P.; Parrish, D. A.; Shreeve, J. M. Journal of the American Chemical Society, 2015, 137, 4778-4786.

Energetic Materials with Promising Properties: Synthesis and Characterization of 4, 4’-Bis(5-nitro-1, 2, 3-2H-triazole) Derivatives
He, C.; Shreeve, J.M. Angewandte Chemie Int. Ed. 2015, 54, 6260-6264.

Curious Cases of 3,6-Dinitropyrazolo[4,3-c]pyrazole-based Energetic Cocrystals with High Nitrogen-content: An Alternative to Salt Formation
Zhang, J.; Parrish, D, A.; Shreeve, J. M. Chemical Communications, 2015, 15, 7337-7340

2014 Selected Publications

3D Printing with Nucleic Acid Adhesives
Allen PB, Khaing Z, Schmidt CE, Ellington AD; ACS Biomater Sci Eng. 2014;1(1):19-26.

Investigating the use of porous, hollow glass microspheres in positive lead acid battery plates
Sorge, Matthew; Bean, Thomas; Woodland, Travis; Canning, John; Cheng, I. Frank; Edwards, Dean B. Journal of Power Sources (2014), 266, 496-511.

C5-Amino acid functionalized LNA: positively poised for antisense applications. Chemical Communications
Guenther, Dale C.; Kumar, Pawan; Anderson, Brooke A.; Hrdlicka, Patrick J. (2014), 50 (64), 9007-9009.

Carbohydrate-Functionalized Locked Nucleic Acids: Oligonucleotides with Extraordinary Binding Affinity, Target Specificity, and Enzymatic Stability. Organic Letters
Kaura, Mamta; Guenther, Dale C.; Hrdlicka, Patrick J. (2014), 16(12), 3308-3311.

C5-Alkynyl-Functionalized α-L-LNA: Synthesis, Thermal Denaturation Experiments and Enzymatic Stability 
Kumar, Pawan; Baral, Bharat; Anderson, Brooke A.; Guenther, Dale C.; Oestergaard, Michael E.; Sharma, Pawan K.; Hrdlicka, Patrick J. Journal of Organic Chemistry (2014), 79(11), 5062-5073.

Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid). Journal of Organic Chemistry
Kumar, Pawan; Oestergaard, Michael E.; Baral, Bharat; Anderson, Brooke A.; Guenther, Dale C.; Kaura, Mamta; Raible, Daniel J.; Sharma, Pawan K.; Hrdlicka, Patrick J. (2014), 79(11), 5047-5061.

Insensitive Nitrogen-Rich Materials Incorporating the Nitroguanidyl Functionality
Zhang, Q., He, C.; Yin, P.; Shreeve, J. M. Chemistry – An Asian Journal, 2014, 9, 212-217.

1,2,3-Triazolo[4,5,-e]furazano[3,4,-b]pyrazine 6-oxide - A Fused Heterocycle with a Roving Hydrogen Forms a New Class of Insensitive Energetic MaterialsThottempudi, V.; Yin, P.; Zhang, J.; Parrish, D. A.; Shreeve, J. M. Chemistry – A European Journal, 2014, 20, 542-548.

Energetic MOFs as High Explosives: A New Concept for Energetic Materials
Zhang, Q.; Shreeve, J. M. Angewandte Chemie Int. Ed. 2014, 53, 2540-2542.

Borohydride Ionic Liquids and Borane/Ionic Liquid Solutions as Hypergolic Fuels with Superior Low Ignition Delay Times
Li, S.; Gao, H.; Shreeve, J. M. Angewandte Chemie Int. Ed. 2014, 53, 2969-2972.

Polynitro-substituted Pyrazoles and Triazoles as Potential Energetic Materials and Oxidizers
Yin, P.; Zhang, J.; He, C.; Parrish, D. A.; Shreeve, J. M. Journal of Materials Chemistry A, 2014, 2, 3200-3208.

3,3'-Dinitroamino-4,4'-azoxyfurazan and Its Derivatives: An Assembly of Diverse N-O Building Blocks for High-performance Energetic Materials
Zhang, J.; Shreeve, J. M. Journal of the American Chemical Society, 2014, 136, 4437-4445.

The effects of conformational changes on the native fluorescence of aqueous humic materials
Shaffer, Leah; Von Wandruszka, Ray. American Chemical Science Journal (2014), 4(3), 326-336.

The physico-chemical properties and biostimulative activities of humic substances regenerated from lignite
David, Jan; Smejkalová, Daniela; Hudecová, Sárka; Zmeskal, Oldrich; von Wandruszka, Ray; Gregor, Tomás; Kucerík, Jirí. SpringerPlus, 3 (156), (2014).

Carbonate-H2O2 leaching for sequestering uranium from seawater
Pan, Horng-Bin; Liao, Weisheng; Wai, Chien M.; Oyola, Yatsandra; Janke, Christopher J.; Tian, Guoxin; Rao, Linfeng. Dalton Transactions (2014), 43(28), 10713-10718.

Supercritical fluid extraction and separation of uranium from other actinides
Quach, Donna L.; Mincher, Bruce J.; Wai, Chien M. Journal of Hazardous Materials (2014), 274, 360-366.

Characteristics of an oxa-diamide-HNO3 extractant in the supercritical fluid extraction of uranium
Wang, Joanna S.; Liao, Weisheng; Wai, Chien M.; Yu, JyaJyun; Chiu, KongHwa. Journal of Radioanalytical and Nuclear Chemistry (2014), 299(3), 1693-170.

Ultrasound-assisted synthesis of PbS quantum dots stabilized by 1,2-benzenedimethanethiol and attachment to single-walled carbon nanotubes
Das, Anirban; Wai, Chien M. Ultrasonics Sonochemistry (2014), 21(2), 892-900.

2013 Selected Publications

Synthesis and Characterization of Oligodeoxyribonucleotides Modified with 2'-Amino-alpha-L-LNA Adenine Monomers: High-affinity Targeting of Single-Stranded DNA
N. K. Andersen, B. A. Anderson, J. Wengel and P. J. Hrdlicka, J. Org. Chem., doi: 10.1021/jo4022937 2013

Recognition of mixed-sequence DNA duplexes: Design guidelines for Invaders based on 2'-O-(pyren-1-yl)methyl-RNA monomers
S. Karmakar, D. C. Guenther and P. J. Hrdlicka, J. Org. Chem., doi: 10.1021/jo402085v. 2013

Identification and characterization of 2nd generation Invader LNAs for mixed-sequence recognition of double-stranded DNA
S. P. Sau, A. S. Madsen, P. Podbevsek, N. K. Andersen, T. S. Kumar, S. Andersen, R. L. Rathje, B. A. Anderson, D. C. Guenther, S. Karmakar, P. Kumar, J. Plavec, J. Wengel and P. J. Hrdlicka, J. Org. Chem., 2013, 78, 9560-9570 (“Featured Article”).

Sandwich assay for mixed-sequence recognition of double-stranded DNA: Invader-based detection of targets specific to foodborne pathogens
B. Denn, S. Karmakar, D. C. Guenther and P. J. Hrdlicka, Chem. Commun., 2013 DOI:10.1039/C3CC45705B

Dehydroaromatization with V2O5
Karki, M.; Araujo, H. C.; Magolan, J. Synlett 2013, 24, 1675-1678.

Highest Measured Anodic Stability in Aqueous Solutions: Graphenic Electrodes from the Thermolyzed Asphalt Reaction
I. Francis Cheng, Yuqun Xie, Isaiah Owusu Gyan, Nolan R. Nicholas, RSC Advances, 2013, 3(7), 2379-2384.

Invaders: Recognition of Double-Stranded DNA using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methylribonucleotides
B. A. Didion, S. Karmakar, D. C. Guenther, S. Sau, J. P. Verstegen and P. J. Hrdlicka*, ChemBioChem, 2013, 14, 1534-1538.

Probing Uranyl(VI) Speciation in the Presence of Amidoxime Ligands using Electrospray Ionization Mass Spectrometry
Mustapha, A. M.; Pasilis, S. P. Rapid Commun. Mass Spectrom. 2013. 27, 2135–2142.

2012 Selected Publications

Sulfur as an Important Co-factor in the formation of Multilayer Graphene in the Thermolyzed Asphalt Reaction
Yuqun Xie, Simon D. McAllister, Seth A. Hyde, Jency Pricilla Sundararajan , B. A. Fouetio Kengne, David N. McIlroy, and I. Francis Cheng* Journal of Materials Chemistry, 2012, 22, 5723-5729.

DNA Strands with Alternating Incorporations of LNA and 2'-O-(pyren-1-yl)methyluridine: SNP-discriminating RNA Detection Probes
S. Karmakar and P. J. Hrdlicka,Chem . Sci., doi: 10.1039/C3SC50726B (2012)

Fluorescent Intercalator Displacement Replacement (FIDR) Assay: Determination of Relative Thermodynamic and Kinetic Parameters in Triplex Formation - A Case Study using Triplex-forming LNAs
S. P. Sau, P. Kumar, P. K. Sharma and P. J. Hrdlicka, Nucleic Acids Res., 2012, 40, e162.

Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines
Mamta Kaura, Pawan Kumar and Patrick J. Hrdlicka. Org. Biomol. Chem., 2012

C2’-Pyrene-functionalized Triazole-linked DNA: Universal Hybridization to DNA/RNA
S. P. Sau and P. J. Hrdlicka, J. Org. Chem., 2012, 77, 5-16 (cover article).

"Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation
Jakob Magolan, Nathan B.P. Adams, Hiroko Onozuka, Natasha L. Hungerford, Hiroyasu Esumi, Mark. J. Coster.ChemMedChem 2012, 7(5), 766-770

Directed Remote Aromatic Metalations: Mechanisms and Driving Forces
David Tilly, Jakob Magolan, Jacques Mortier. Chemistry - A European Journal 2012, 18, 3804-3820

5-HT3 and 5-HT4 Receptors Contribute to the Anti-motility Effects of Garcinia buchananii Bark Extract in the Guinea Pig Distal Colon.
Boakye, P. A.; Stenkamp-Strahm, C.; Bhattarai, Y.; Heckman, M. D.; Brierley, S. M.; Pasilis, S. P.; Balemba, O. B.*Neurogastroenterol. Motil. 2012, 24, e27–e40.

An Experimental Estimate of the Relative Aromaticity of the Cyclooctatetraene Dianion by Fusion to Dimethyldihydropyrene
R. H. Mitchell, P. Zhang, D. J. Berg and R. V. Williams, “Chem. Commun., 2012, 48, 8144.

Experimental Verification of the Homoaromaticity of 1,3,5-Cycloheptatriene and the Evaluation of the Aromaticity of Tropone and the Tropylium Cation Using the Dimethyldihydropyrene Probe
R. V. Williams, W. D. Edwards, P. Zhang, D. J. Berg and R. H. Mitchell J. Am. Chem. Soc., 2012, 134, 16742.

Synthesis of graphene paper from pyrolyzed asphalt
I. Francis Cheng, R. Allen Gonzales, Yuqun Xie, Przemysław R. Brejna, Jency Pricilla Sundararajan, B. A. Fouetio Kengne, D. Eric Aston, David N. McIlroy, Jeremy D. Foutch and Peter R. Griffiths Carbon, 2011, 49, 2852-2861.

Department of Chemistry

Physical Address:
Renfrew Hall 116

Mailing Address:
875 Perimeter Dr, MS 2343
Moscow, ID 83844-2343

Phone: 208-885-6552

Fax: 208-885-6173


Web: Department of Chemistry