Paul Andrew Rowley
Paul Andrew Rowley
Research: Biology, Virology, Microbiology, Evolution, Virus-Host Interactions
- Ph.D., The University of Aberdeen (UK), Molecular Biology, 2007
- B.A., The University of Warwick (UK), Microbiology and Virology, 2002
Dr. Rowley’s research interests are centered on the complex interactions that occur between a virus and it’s host. The Rowley laboratory aims to better understand how viruses hijack host proteins and how antiviral host proteins thwart virus replication. The laboratory uses both mammalian cell culture and the model eukaryote Saccharomyces cerevisiae to understand how viral antagonism has shaped the evolution and function of host proteins. Dr. Rowley is currently investigating the mechanistic details of viral nuclear entry via the nuclear pore complex in primates, and how RNA metabolism has evolved as a potent antiviral defense mechanism within Saccharomyces yeasts.
"The vermin only tease and pinch
Their foes superior by an inch.
So, naturalists observe, a flea
Has smaller fleas that on him prey;
And these have smaller still to bite 'em,
And so proceed ad infinitum."
- Jonathan Swift
My B.A. at The University of Warwick (UK) introduced me to the fascinating aspects of how viruses cause disease. After working in the food safety industry I began a PhD studying the biology of bacterial viruses (Aberdeen, UK). After relocating to Texas, I studied viruses that infect higher organisms, including yeast and primates (including humans!) using techniques from molecular biology and evolution. I continued this work as a postdoc at The Biofrontiers Institute (Boulder, CO).
- Rowley PA*, Kachroo AH*, Ma CH, Macieszak A, Guga P, Jayaram M. (2015). Methylphosphonate substitution for the scissile phosphate and active site mutants reveal the stereochemical course of tyrosine recombination: Nucleic Acids Res, 43(12), 6023–6037.
- McBee RM, Rozmiarek SA, Meyerson NR, Rowley PA, Sawyer SL. (2015). The effect of species representation on the detection of positive selection in primate gene data sets. Mol Biol Evol, 32(4): 1091–1096.
- Meyerson NR, Rowley PA, Swan CH, Le DT, Wilkerson GK, Sawyer SL. (2014). Positive selection of primate genes that promote HIV-1 replication. Virology, 454-455, 291–298.
- Liu YT, Sau S, Ma CH, Kachroo AH, Rowley PA, Chang KM, Fan HF, Jayaram M. (2014). The partitioning and copy number control systems of the selfish yeast plasmid: an optimized molecular design for stable persistence in host cells. Microbiol Spectr, 2014;2(5).
- Ma CH, Cui H, Hajra S, Rowley PA, Fekete C, Sarkeshik A, Ghosh SK, Yates JR 3rd, Jayaram M. (2012). Temporal sequence and cell cycle cues in the assembly of host factors at the yeast 2 micron plasmid partitioning locus. Nucleic Acids Res, 41, 2340–2353.
- Rowley PA, Kachroo AH, Ma CH, Macieszak A, Guga P, Jayaram M. (2010) Electrostatic suppression allows tyrosine site-specific recombination in the absence of a conserved catalytic arginine. J Bio Chem, 285(30), 22976-85.
- Rowley PA, Smith, MC. (2008) Role of the N-terminal domain of φC31 integrase in attB-attP synapsis. J Bacteriol, 190, 6918-6921.
- Rowley PA, Smith MC, Younger E, Smith, MC. (2008) A motif in the C-terminal domain of φC31 integrase controls the directionality of recombination. Nucleic Acids Res, 36, 3879-3891.
- ASM Science Teaching Fellowship, The American Society for Microbiology, October 2014.
- Winner of the Rom Rhome International Professional Development Award, The University of Texas at Austin, February 2014.
- Second Place - Young Microbiologist of the Year Award, The Society for General Microbiology, June 2006.