University of Idaho - I Banner
A student works at a computer


U of I's web-based retention and advising tool provides an efficient way to guide and support students on their road to graduation. Login to VandalStar.

Readily Accessible Mimics for DNA Targeting

OTT Case 11-016 | Patent Pending

Full characterization of DNA-targeting applications with N2'-Pyrene-functionalized 2'-amino-alpha-L-LNAs has been limited by the challenging synthesis of these compounds. Researchers at the university have developed more readily accessible functional mimics. These mimics include a series of O2'-intercalator-functionalized uridine and N2'-intercalator-functionalized 2'-N-methyl-2'-aminouridine monomers. Their mimic functionality has been demonstrated via thermal denaturation, UV-visible absorption and fluorescence spectroscopy experiments.