Readily Accessible Mimics for DNA Targeting

OTT Case 11-016 | Patent Pending

Full characterization of DNA-targeting applications with N2'-Pyrene-functionalized 2'-amino-alpha-L-LNAs has been limited by the challenging synthesis of these compounds. Researchers at the University have developed more readily accessible functional minics. These mimics include a series of O2'-intercalator-functionalized uridine and N2'-intercalator-functionalized 2'-N-methyl-2'-aminouridine monomers. Their minic functionality has been demonstrated via thermal denaturation, UV-visible absorption and fluorescence spectroscopy experiments.