Jill Johnson, Biological Sciences, Receives NIH Grant
October 29, 2019
Professor Jill Johnson, in the Department of Biological Sciences and the College of Science, has been awarded a four-year, $1 million grant from the National Institutes of Health. These funds will be used to better understand the basic mechanism of how the molecular chaperone Hsp90 interacts with other proteins, called clients, in order to regulate their function. Hsp90 is a global cellular regulator that controls the function of up to 15% of all cellular proteins, including many proteins that drive cancerous cell growth. Drugs that target Hsp90 block the function of cancer-causing proteins and stop tumor growth but are too toxic for general use. This award will allow Johnson and her collaborators at the University of Alberta and the Technical University of Munich to better understand Hsp90 function, paving the way toward development of more selective inhibitors of Hsp90 function that have fewer toxic effects.
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