Veterinary Medical Research & Dev.

Innovator | Keun Seok Seo 
 

The health and well-being of livestock is an important issue throughout Idaho and the U.S. Keun Seok Seo of the microbiology, molecular biology and biochemistry department has done much to advance the practice of keeping cattle healthy.

In the past year, two separate technologies related to the health of cattle have been licensed by Veterinary Medical Research and Development, Inc., or VMRD.

Regulatory T-cells play a central role in the suppression of the immune response to maintain immune homeostasis. A lack of regulatory T-cells results in autoimmune disease and hyper allergy. To detect the activation of T-cells via the transcription of FOXP3, monoclonal antibodies are directed to transcription factor FOXP3.
 
The second technology involves another monoclonal antibody, LND41A. These are directed to dendritic cells, which are antigen presenting cells (APCs). Dendritic cells are professional phagocytes that engulf foreign antigens such as bacterium, viruses, and parasites. The cells then present the pathogens to the T-cells, resulting in the activation of T-cells, which protect cattle from pathogens. This monoclonal antibody allows the identification of activated dendritic cells and indicates when an immune response is beginning in cattle.