C5-functionalized Pyrimide Nucleotides

OTT Case 09-026 | Patent 8,518,908Patent 8,912,318

Oligonucleotides exhibit high thermal affinity toward complementary single stranded DNA, RNA and doubled stranded DNA, along with high mismatch discrimination and significantly improved stability against nucleases. The nature of the C5-substitutent of these building blocks influences celluar uptake of the oligonucleotide and their pharmacokinetic.