Professor Tsosie has written and published widely on doctrinal and theoretical issues related to tribal sovereignty, environmental policy, and cultural rights. Professor Tsosie is the author of many prominent articles dealing with cultural resources and cultural pluralism. She has used this work as a foundation for her newest research, which deals with Native rights to genetic resources.
Professor Tsosie, who is of Yaqui descent, has also worked extensively with tribal governments and organizations. She serves as a Supreme Court Justice for the Fort McDowell Yavapai Nation and as a Court of Appeals Judge for the San Carlos Tribal Court of Appeals. Professor Tsosie was appointed as a Willard H. Pedrick Distinguished Research Scholar in 2005. Prior to this, she held the title of Lincoln Professor of Native American Law and Ethics.
She is an Affiliate Professor for the American Indian Studies Program. She is the co-author of a federal Indian law casebook entitled American Indian Law: Native Nations and the Federal System. Tsosie was awarded a Woodrow Wilson Fellowship and received the American Bar Association's "2002 Spirit of Excellence Award." She is the 2006 recipient of the "Judge Learned Hand Award" for Public Service.